HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → 1-[2-(3,4-dihydro-1(2H)-benzopyran-4-yl)ethyl]-4-(3,4-dimethoxyphenyl)piperazine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-bromoethyl-3,4-dihydro-(2H)-benzopyran | HCID 21756481 | — |
| Reactant | 1-(3,4-Dimethoxyphenyl)piperazine dihydrochloride | HCID 22625407 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 1-[2-(3,4-dihydro-1(2H)-benzopyran-4-yl)ethyl]-4-(3,4-dimethoxyphenyl)piperazine dihydrochloride | HCID 22154273 | — |
Reaction Steps
The A isomer of 1-[2-(3,4-dihydro-1(2H)-benzopyran-4-yl)ethyl]-4-(3,4-dimethoxyphenyl)piperazine dihydrochloride is prepared by following the procedure of Example 1 but starting with the A isomer of 4-(2-bromoethyl -3,4-dihydro-(2H)-benzopyran (0.86 g), 1-(3,4-dimethoxyphenyl)piperazine dihydrochloride (1.10 g) and then dry potassium carbonate (1.38 g) and potassium iodide (0.6 g) in 2-butanone (15 cc).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04977166 |
| Source dataset | uspto-grants-1990_12 |
| ORD ID | ord-32caed68eb754ebabc0c6b73733237c8 |
| Source note | uspto-grants-1990_12 |