HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → 1-[2-(3,4-dihydro-1(2H)-benzopyran-4-yl)ethyl]-4-(3,4-dimethoxyphenyl)piperidine fumarate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-(2-bromoethyl)-3,4-dihydro-2H-benzopyran | HCID 14330282 | — |
| Reactant | 4-(3,4-Dimethoxyphenyl)piperidine dihydrochloride | HCID 20068758 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 1-[2-(3,4-dihydro-1(2H)-benzopyran-4-yl)ethyl]-4-(3,4-dimethoxyphenyl)piperidine fumarate | HCID 22154283 | — |
Reaction Steps
The B isomer of 1-[2-(3,4-dihydro-1(2H)-benzopyran-4-yl)ethyl]-4-(3,4-dimethoxyphenyl)piperidine fumarate is prepared by following the procedure of Example 16 but starting with the B isomer of 4-(2-bromoethyl)-3,4-dihydro-(2H)-benzopyran (1.5 g) and 4-(3,4-dimethoxyphenyl)piperidine dihydrochloride (1.78 g), followed by potassium carbonate (1.71 g) and potassium iodide (1.03 g) in 2-butanone (50 cc).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04977166 |
| Source dataset | uspto-grants-1990_12 |
| ORD ID | ord-5576115eac87410e8aa3a77770961592 |
| Source note | uspto-grants-1990_12 |