HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → 1-[2-(3,4-Dihydro-1(2H)-benzopyran-4-yl)ethyl]-4-(4-hydroxy-3-methoxyphenyl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | 4-(2-bromoethyl)-3,4-dihydro-2H-benzopyran | HCID 14330282 | — |
| Reactant | 2-Methoxy-4-(piperidin-4-yl)phenol | HCID 22154252 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 1-[2-(3,4-Dihydro-1(2H)-benzopyran-4-yl)ethyl]-4-(4-hydroxy-3-methoxyphenyl)piperidine | HCID 22154226 | — |
Reaction Steps
1-[2-(3,4-Dihydro-1(2H)-benzopyran-4-yl)ethyl]-4-(4-hydroxy-3-methoxyphenyl)piperidine is prepared by proceeding as in Example 48 but starting with 4-(4-hydroxy-3-methoxyphenyl)piperidine, 4-(2-bromoethyl)-3,4-dihydro-2H-benzopyran (0.49 g) and potassium iodide (0.5 g) in 2-butanone (35 cc).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04977166 |
| Source dataset | uspto-grants-1990_12 |
| ORD ID | ord-a7936aebf7e4409cb6a49e00715abfc4 |
| Source note | uspto-grants-1990_12 |