HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl acrylate → HCID 19989926, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl acrylate | HCID 15458 | — |
| Reactant | Acrylate | HCID 25188 | — |
| Reactant | Benzeneacetonitrile, 4-bromo- | HCID 27914 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Catalyst | Cobalt(II) chloride | HCID 24288 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Product | HCID 19989926 | HCID 19989926 | — |
Reaction Steps
p-Bromophenylacetonitrile is first condensed with t-butyl acrylate under conditions of the palladium acetate catalyzed Heck reaction. The resulting acrylate is hydrogenated with palladium on charcoal catalyst followed by reduction (of the cyano group) with sodium borohydride in the presence of cobalt(II) chloride to yield t-butyl p-(2-aminoethyl)-phenylpropionate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04977144 |
| Source dataset | uspto-grants-1990_12 |
| ORD ID | ord-46f5f5ef186f4f01887a54452d647971 |
| Source note | uspto-grants-1990_12 |