tert-Butyl acrylate → HCID 22154047, compound

Participants

Reaction Steps

p-Bromophenylethanol is first condensed with t-butyl acrylate under conditions of the palladium acetate catalyzed Heck reaction. The resulting acrylate is hydrogenated with palladium on charcoal catalyst to yield t-butyl p-(2-hydroxyethyl)-phenylpropionate, which is converted to the corresponding tosylate by treatment with tosyl chloride in pyridine.

Provenance & Evidence