HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Isocyanate → N-(4-benzyloxybenzyl)-O-methylcarbamoylacetohydroxamic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Isocyanate | HCID 12228 | — |
| Reactant | N-(4-benzyloxybenzyl)acetohydroxamic acid | HCID 129265 | — |
| Catalyst | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(4-benzyloxybenzyl)-O-methylcarbamoylacetohydroxamic acid | HCID 15670601 | 82.6% |
Reaction Steps
A mixture of N-(4-benzyloxybenzyl)acetohydroxamic acid (1.35 g), methyl isocyanate (0.65 g) and 1,8-diazabicyclo [5.4.0]undec-7-ene catalyst (1 drop) in tetrahydrofuran (10 ml) was stirred for 3 hours then left overnight to provide N-(4-benzyloxybenzyl)-O-methylcarbamoylacetohydroxamic acid (1.35 g) m.pt. 101°-102°[from ethyl acetate-light petroleum (b.pt. 60°-80°)].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04977188 |
| Source dataset | uspto-grants-1990_12 |
| ORD ID | ord-6252bee1c8b34a8e877e3655a6f31a3c |
| Source note | uspto-grants-1990_12 |