HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-cyano-7-(3-(quinolin-2-ylmethoxy)benzyloxy)-4-oxo-4H-1-benzopyran
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-cyano-7-hydroxy-4-oxo-4H-1-benzopyran | HCID 9989995 | — |
| Reactant | 2-(3-Chloromethylphenoxy)methylquinoline | HCID 14501706 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 2-cyano-7-(3-(quinolin-2-ylmethoxy)benzyloxy)-4-oxo-4H-1-benzopyran | HCID 14842366 | — |
Reaction Steps
To 2-cyano-7-hydroxy-4-oxo-4H-1-benzopyran (11.87 mmoles) and 2-((3-chloromethylphenoxy)methyl)quinoline (11.87 mmoles) in dimethylsulfoxide (20 ml) is added powdered sodium hydroxide (0.475 g). After one week the reaction mixture is poured into ice water and the resulting precipitate collected and purified by HPLC to give 2-cyano-7-(3-(quinolin-2-ylmethoxy)benzyloxy)-4-oxo-4H-1-benzopyran which is used directly in the next step
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04977162 |
| Source dataset | uspto-grants-1990_12 |
| ORD ID | ord-26c4e5f6e6d84f929a179fd8290e05c0 |
| Source note | uspto-grants-1990_12 |