HCID 54004042, compound → HCID 53876049, compound

HRID 1110935Notes

Reaction equation

HRID 1110935 reaction equation
[O:1]=[C:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]2[CH:13]=[N:14][C:15]([C:16](=[N:18][OH:19])[NH2:17])=[C:5]2[CH2:4][O:3]1>C(OC(=O)C(C)C)(=O)C(C)C>[CH:8]([C:9]1[O:19][N:18]=[C:16]([C:15]2[N:14]=[CH:13][N:6]3[C:7]4[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=4[C:2](=[O:1])[O:3][CH2:4][C:5]=23)[N:17]=1)([CH3:2])[CH3:7]

Participants

3

Reactant 1

HCID 54004042HCID 54004042, compound

Product 1

HCID 53876049HCID 53876049, compoundYield 112.8%

Reagents, catalysts & solvents 1

HCID 7346Isobutyric anhydrideSolvent

Procedure

5,6-Dihydro-6-oxo-4H-imidazo[1,5-a][4,1]benzoxazepine-3-amidoxime (2 g, 8 mmole) in isobutyric anhydride (6 ml) was heated at 150° C. for 1.5 hours. The crude product in ethyl acetate:hexane (1:1) was chromatographed on silica and then crystallised from ethyl acetate:hexane to give the product (1.4 g, 58%), m.p. 143°-144° C.

Workup

  1. customThe crude product in ethyl acetate:hexane (1:1) was chromatographed on silica
  2. customcrystallised from ethyl acetate

Sources & evidence

ORD record
ord-c7eb78911a3b4869a5c39e1b469efc68
Source dataset
uspto-grants-1990_12
Patent number
US04977258

Reaction notes

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