Acetic Anhydride → 7-Chloro-3-(5-methyl-1,2,4-oxadiazol-3-yl)-5,6-dihydro-6-oxo-4H-imidazo[1,5-a][4,1]benzoxazepine

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Reaction Steps

7-Chloro-5,6-dihydro-6-oxo-4H-imidazo[1,5-a]-[4,1]benzoxazepine-3-amidoxime (3 g, 0.01 mole) in acetic anhydride (9 ml) was heated at 150° C. for 3 hours. The crude product in ethyl acetate was chromatographed on silica and then crystallised from acetone to give the product (2.1 g, 66%), m.p. 253°-255° C.

Provenance & Evidence