7-Chloro-5,6-dihydro-6-oxo-4H-imidazo[1,5-a]-[4,1]benzoxazepine-3-amidoxime → 7-Chloro-3-(5-pentyl-[1,2,4]oxadiazol-3-yl)-4H-5-oxa-2,10b-diaza-benzo[e]azulen-6-one

Participants

Reaction Steps

7-Chloro-5,6-dihydro-6-oxo-4H-imidazo[1,5-a][4,1]benzoxazepine-3-amidoxime (2 g, 7 mmole) in caproic anhydride (8 ml) was heated at 150° C. for 30 minutes. The crude product in ethyl acetate:hexane (1:1) was chromatographed on silica to give the product (1.6 g, 63%), m.p. 110°-112° C.

Provenance & Evidence