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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1110956Generated: November 4, 2026

Sodium bis(trimethylsilyl)amide → Isophthalonitrile

https://huagongshe.com/reaction/1110956

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium bis(trimethylsilyl)amideHCID 2724254—
ReactantHCID 19887125HCID 19887125—
ReactantHCID 19887147HCID 19887147—
ProductIsophthalonitrileHCID 12276—

Reaction Steps

(kk) by using 3,5-dicyanobenzylidenetriphenylphosphorane prepared in situ by means of 3,5-dicyanobenzyltriphenylphosphonium bromide and sodium bis(trimethylsilyl)amide there is obtained 5-[(Z)-2-(1R,4S,5S,8R)-4,8-dimethyl-7-oxo-2,3-dioxabicyclo[3.3.1]nonan-4-yl]vinyl]isophthalonitrile [m.p. 185°]:

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04977184
Source datasetuspto-grants-1990_12
ORD IDord-95f5372b32dd4220a46ec9d59333c7d3
Source noteuspto-grants-1990_12