Iodine → HCID 14599974, compound

Participants

Reaction Steps

Added to 1.08 g of 2-(2-methoxybenzoyl)-4,5-dichloropyrrole were 16 ml of a 1:1 mixture of dioxane and water and 4 ml of a 1 N aqueous solution of sodium hydroxide to dissolve the pyrrole derivative, followed by the addition of 12 ml of an aqueous solution containing 1.2 g of iodine and 1.44 g of sodium iodide. The resultant mixture was stirred at room temperature for 15 hours. Thereafter, 40 ml of a 1 N aqueous solution of sodium thiosulfate was added, followed by stirring for 1 hour. Crystals thus deposited were collected by filtration, washed with water and then dried to obtain 1.24 g of 2-(2-methoxybenzoyl)-3-iodo-4,5-dichloropyrrole (Compound No. 1).

Provenance & Evidence