HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 2-Chloroisonicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Phosphorus pentachloride | HCID 24819 | — |
| Reactant | 4-Pyridinecarboxylic acid, 1-oxide | HCID 26130 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Chloroisonicotinic acid | HCID 236985 | 66% |
Reaction Steps
87 g of isonicotinic acid N-oxide, 350 ml of phosphorus oxychloride and 192 g of phosphorus pentachloride were mixed and refluxed for 3 hours. The reaction mixture was poured into water and left to stand overnight. The resulting precipitate was collected by filtration, and recrystallized from ethanol to give 65 g (66 %) of 2-chloro-4-pyridinecarboxylic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04977267 |
| Source dataset | uspto-grants-1990_12 |
| ORD ID | ord-de68a7f6617c422895bd6a770e33f3d6 |
| Source note | uspto-grants-1990_12 |