反应详情

One gram of sodium hydroxide in 4.0 ml of water is added to a mixture of 4.0 g of 2-(3-trifluoromethylphenyl)-3-amino-5-phenyl-2-cyclopentenone in 80 ml of methylene chloride at room temperature followed by the addition of 1.46 g of allyl bromide and 0.27 g of benzyltriethylammonium chloride. The resulting two-phase mixture is stirred at room temperature until the reaction is completed. The reaction mixture is washed three times with water, dried over magnesium sulfate and concentrated in vacuo. The residue is typically purified by chromatography to yield the title compound.

1. washThe reaction mixture is washed three times with water
2. dry with materialdried over magnesium sulfate
3. concentrationconcentrated in vacuo
4. customThe residue is typically purified by chromatography