HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → Methyl 4,4,4-trifluoro-3-oxobutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Dimethyl 2,6-bis(trifluoromethyl)-2,6-dihydroxy-4-isobutyl-tetrahydro-3,5-pyrandicarboxylate | HCID 13745974 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Methyl 4,4,4-trifluoro-3-oxobutanoate | HCID 550266 | — |
| Product | Dimethyl 2,6-bis(trifluoromethyl)-2,6-dihydroxy-4-isobutyl-3,5-piperidinedicarboxylate | HCID 13745991 | — |
Reaction Steps
To a solution of 344 g (0.920 mole) crude product from Example b in 500 ml of tetrahydrofuran (THF) is passed 58 g (3.41 mole) of gaseous ammonia for 3 hours. The reaction mixture is concentrated and the residue (332 g) is recrystallized from hexaneether to give 53.7 g (13% yield from methyl trifluoroacetoacetate) of the desired product as a white solid, m.p. 102°-106° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04978384 |
| Source dataset | uspto-grants-1990_12 |
| ORD ID | ord-6d330343c00c43a08dd4836d024545a7 |
| Source note | uspto-grants-1990_12 |