Iodoethane → HCID 22153308, compound

Participants

Reaction Conditions

Reaction Steps

To a three-neck flask fitted with a mechanical stirrer, a thermometer, and a condenser is added 124.0 g (1 mole) of 4-fluorobenzaldehyde, 117.2 g (1 mole) of 6-amino-1-hexanol, 276.4 g (2 mole) of potassium carbonate, and dimethylsulfoxide. The reaction mixture is heated at 95° C. for about 3 hours until thin-layer chromatography indicates no more 4-fluorobenzaldehyde is present After cooling to room temperature, 156 g (1 mole) of ethyl iodide is added dropwise, and the reaction is stirred at room temperature for 5 hours The solution is poured into a four-fold excess of ice water, and the solid product is collected by filtration and purified by recrystallization from water.

Provenance & Evidence