Benzoyl Peroxide → HCID 22153312, compound

Participants

Reaction Steps

A stirred solution of 213.0 g (0.7 mole) of 1-trifluoroacetyl-2-(4-methylphenyl)benzimidazole, 125.0 g (0.7 mole) of N-bromosuccinimide, and 3.39 g (2 mole %) of benzoyl peroxide in carbon tetrachloride is heated at reflux for 20 hours. After cooling to room temperature, the reaction is diluted by the addition of carbon tetrachloride, and the solid byproducts are removed by filtration. The filtrate is concentrated in vacuo, and the product is purified by recrystallization from tetrahydrofuran.

Provenance & Evidence