Methanol → 2-Cyclohexylpropanal dimethylacetal

HRID 1111098Notes

Reaction equation

HRID 1111098 reaction equation
[CH:1]1([CH:7]([CH3:10])[CH:8]=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:11]([O-])([O-])[O:12]C.[Cl-].[NH4+].[CH3:18]O>>[CH3:18][O:9][CH:8]([O:12][CH3:11])[CH:7]([CH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1)[CH3:10]

Participants

5

Reactant 4

HCID 887MethanolHCID 25517Ammonium ChlorideHCID 95560Cyclohexaneacetaldehyde, alpha-methyl-HCID 53629101Methylorthoformate

Product 1

HCID 147453352-Cyclohexylpropanal dimethylacetal

Procedure

Into a 200 ml round bottom flask 50 ml of methanol, 30.0 g of 2-cyclohexylpropanal, 36.1 g of methyl orthoformate, and 0.5 g of ammoniumchloride were charged and the mixture was stirred at room temperature for 12 hours. After washing the resulting reaction mixture with water, the residue was distilled to prepare 37.5 g of Compound No. 4 (purity: 99.3%, boiling point: 83° C./5 mmHg). The compound was a colorless, transparent liquid having a floral and fruity odor.

Workup

  1. washAfter washing
  2. customthe resulting reaction mixture with water
  3. distillationthe residue was distilled
  4. customto prepare 37.5 g of Compound No

Sources & evidence

ORD record
ord-e567c0ef983e41018d9ea942340d5588
Source dataset
uspto-grants-1990_12
Patent number
US04978653

Reaction notes

Loading…