反应详情

A mixture of ethyl 5-chloro-3-methyl-2-benzofurancarboxylate (52.5 g, 0.22 mol), N bromosuccinimide (39.15 g, 0.22 mol) and benzoyl peroxide (0.4 g) in carbon tetrachloride (750 ml) was stirred and refluxed for 10 hours. The mixture was cooled, filtered and the filtrate was concentrated. The crude product was recrystallized from hexane to give 52.8 g (76%) of ethyl 3-bromomethyl-5-chloro-2-benzofurancarboxylate: mp 112°-114° C.

1. temperaturerefluxed for 10 hours
2. temperatureThe mixture was cooled
3. filtrationfiltered
4. concentrationthe filtrate was concentrated
5. customThe crude product was recrystallized from hexane