HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Eseroline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Physostigmine | HCID 5983 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Eseroline | HCID 119198 | — |
Reaction Steps
hydrolyzing physostigmine in absolute ethanol under a nitrogen atmosphere at ambient temperature by treatment with aqueous 5-30% w/w NaOH or KOH solutions, followed by treatment with 1N HCl to obtain eseroline (II) ##STR10## which is purified by crystallization from a 1:1 benzene/petroleum ether mixture;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04978673 |
| Source dataset | uspto-grants-1990_12 |
| ORD ID | ord-5feb99b4516941d486f59a90da23203e |
| Source note | uspto-grants-1990_12 |