Hydrochloric Acid → HCID 11043160, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-hydroxy-2-cyanomethyl-2,4,6,7-tetramethyl-2,3-dihydrobenzofuran in methanol (5 ml) was added a solution of sodium hydroxide (0.5 g) in water (5 ml). The mixture was heated for three hours under reflux under argon atmosphere. The reaction mixture was cooled to 0° C. neutralized with 2N-HCl. The reaction product was extracted with ethyl acetate. The extract solution was washed with water, dried and concentrated, and then crystallized from ethyl acetate - isopropyl ether to afford the desired 2-(5-hydroxy-2,4,6,7-tetramethyl-2,3-dihydrobenzofuran-2-yl)acetic acid (Compound 1) (0.1 g).

Provenance & Evidence