Methyl propiolate → HCID 15079804, compound

HRID 1111196Notes

Reaction equation

HRID 1111196 reaction equation
[NH2:1][C:2]1[CH2:8][N:7]=[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[Cl:15])[C:5]2[CH:16]=[C:17]([Cl:20])[CH:18]=[CH:19][C:4]=2[N:3]=1.[C:21](OC)(=[O:24])[C:22]#[CH:23]>CO>[Cl:20][C:17]1[CH:18]=[CH:19][C:4]2[N:3]3[CH:23]=[CH:22][C:21](=[O:24])[N:1]=[C:2]3[CH2:8][N:7]=[C:6]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[Cl:15])[C:5]=2[CH:16]=1

Participants

4

Reactant 2

HCID 13536Methyl propiolateHCID 12569590HCID 12569590, compound

Product 1

HCID 15079804HCID 15079804, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In the manner given in Example 1, 2-amino-7-chloro-5-(o-chlorophenyl)-3H-1,4-benzodiazepine, methyl propiolate and methanol were refluxed. The mixture was chromatographed to give 9-chloro-7-(o-chlorophenyl)pyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one.

Workup

  1. temperaturewere refluxed
  2. customThe mixture was chromatographed

Sources & evidence

ORD record
ord-6869c276480440f2a1222a5c379b7427
Source dataset
uspto-grants-1990_12
Patent number
US04978753

Reaction notes

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