Ethyl propiolate → HCID 15079744, compound

HRID 1111198Notes

Reaction equation

HRID 1111198 reaction equation
[NH2:1][C:2]1[CH2:8][N:7]=[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[Br:15])[C:5]2[CH:16]=[C:17]([Cl:20])[CH:18]=[CH:19][C:4]=2[N:3]=1.[C:21](OCC)(=[O:24])[C:22]#[CH:23]>C(O)C>[Cl:20][C:17]1[CH:18]=[CH:19][C:4]2[N:3]3[CH:23]=[CH:22][C:21](=[O:24])[N:1]=[C:2]3[CH2:8][N:7]=[C:6]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[Br:15])[C:5]=2[CH:16]=1

Participants

4

Reactant 2

HCID 12182Ethyl propiolateHCID 15079733HCID 15079733, compound

Product 1

HCID 15079744HCID 15079744, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner given in Example 1, 2-amino-7-chloro-5-(o-bromophenyl)-3H-1,4-benzodiazepine, ethyl propiolate, and ethanol were refluxed. The mixture was chromatographed to give 9-chloro-7-(o-bromophenyl)pyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one.

Workup

  1. temperaturewere refluxed
  2. customThe mixture was chromatographed

Sources & evidence

ORD record
ord-3f32250c57944f9f975d5d9f79b5355a
Source dataset
uspto-grants-1990_12
Patent number
US04978753

Reaction notes

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