Methyl propiolate → HCID 15079746, compound

HRID 1111200Notes

Reaction equation

HRID 1111200 reaction equation
[NH2:1][C:2]1[CH2:8][N:7]=[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[Cl:15])[C:5]2[CH:16]=[C:17]([N+:20]([O-:22])=[O:21])[CH:18]=[CH:19][C:4]=2[N:3]=1.[C:23](OC)(=[O:26])[C:24]#[CH:25]>CO>[N+:20]([C:17]1[CH:18]=[CH:19][C:4]2[N:3]3[CH:25]=[CH:24][C:23](=[O:26])[N:1]=[C:2]3[CH2:8][N:7]=[C:6]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[Cl:15])[C:5]=2[CH:16]=1)([O-:22])=[O:21]

Participants

4

Reactant 2

HCID 13536Methyl propiolateHCID 15079735HCID 15079735, compound

Product 1

HCID 15079746HCID 15079746, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In the manner given in Example 1, 2-amino-7-nitro-5-(o-chlorophenyl)-3H-1,4-benzodiazepine, methyl propiolate and methanol were refluxed. The mixture was chromatographed to give 9-nitro-7-(o-chlorophenyl)pyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one.

Workup

  1. temperaturewere refluxed
  2. customThe mixture was chromatographed

Sources & evidence

ORD record
ord-40df3b99c4764f1fb35d4bbc7bf7d2f2
Source dataset
uspto-grants-1990_12
Patent number
US04978753

Reaction notes

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