Methyl propiolate → HCID 15079748, compound

HRID 1111202Notes

Reaction equation

HRID 1111202 reaction equation
[NH2:1][C:2]1[CH2:8][N:7]=[C:6]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH3:17])=[CH:11][C:10]=2[O:18][CH2:19][CH3:20])[C:5]2[C:21]([O:25][CH3:26])=[CH:22][CH:23]=[CH:24][C:4]=2[N:3]=1.[C:27](OC)(=[O:30])[C:28]#[CH:29]>CO>[CH3:26][O:25][C:21]1[C:5]2[C:6]([C:9]3[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH3:17])=[CH:11][C:10]=3[O:18][CH2:19][CH3:20])=[N:7][CH2:8][C:2]3[N:3]([CH:29]=[CH:28][C:27](=[O:30])[N:1]=3)[C:4]=2[CH:24]=[CH:23][CH:22]=1

Participants

4

Reactant 2

HCID 13536Methyl propiolateHCID 15079737HCID 15079737, compound

Product 1

HCID 15079748HCID 15079748, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In the manner given in Example 1, 2-amino-6-methoxy-5-(2,4-diethoxyphenyl)-3H-1,4-benzodiazepine, methyl propiolate and methanol were refluxed. The mixture was chromatographed to give 8-methoxy-7-(2,4-diethoxyphenyl)pyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one.

Workup

  1. temperaturewere refluxed
  2. customThe mixture was chromatographed

Sources & evidence

ORD record
ord-5cdc33e72c154f528762a5b8c6ba3519
Source dataset
uspto-grants-1990_12
Patent number
US04978753

Reaction notes

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