Ethyl propiolate → HCID 15079815, compound

HRID 1111203Notes

Reaction equation

HRID 1111203 reaction equation
[NH2:1][C:2]1[CH2:8][N:7]=[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][CH3:16])[CH:10]=2)[C:5]2[C:17]([CH2:23][CH3:24])=[CH:18][C:19]([CH2:21][CH3:22])=[CH:20][C:4]=2[N:3]=1.[C:25](OCC)(=[O:28])[C:26]#[CH:27]>C(O)C>[CH2:23]([C:17]1[C:5]2[C:6]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][CH3:16])[CH:10]=3)=[N:7][CH2:8][C:2]3[N:3]([CH:27]=[CH:26][C:25](=[O:28])[N:1]=3)[C:4]=2[CH:20]=[C:19]([CH2:21][CH3:22])[CH:18]=1)[CH3:24]

Participants

4

Reactant 2

HCID 12182Ethyl propiolateHCID 15079738HCID 15079738, compound

Product 1

HCID 15079815HCID 15079815, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner given in Example 1, 2-amino-6,8-diethyl-5-(m-ethylphenyl)-3H-1,4-benzodiazepine, ethyl propiolate and ethanol were refluxed. The mixture was chromatographed to give 8,10-diethyl-7-(m-ethylphenyl)pyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one.

Workup

  1. temperaturewere refluxed
  2. customThe mixture was chromatographed

Sources & evidence

ORD record
ord-f4f268482b3a472da4ac73afdeba076e
Source dataset
uspto-grants-1990_12
Patent number
US04978753

Reaction notes

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