Ethyl propiolate → HCID 15079751, compound

HRID 1111206Notes

Reaction equation

HRID 1111206 reaction equation
[NH2:1][C:2]1[CH2:8][N:7]=[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[CH:10]=2)[C:5]2[CH:16]=[CH:17][C:18]([S:20][CH2:21][CH3:22])=[CH:19][C:4]=2[N:3]=1.[C:23](OCC)(=[O:26])[C:24]#[CH:25]>C(O)C>[CH2:21]([S:20][C:18]1[CH:17]=[CH:16][C:5]2[C:6]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[CH:10]=3)=[N:7][CH2:8][C:2]3[N:3]([CH:25]=[CH:24][C:23](=[O:26])[N:1]=3)[C:4]=2[CH:19]=1)[CH3:22]

Participants

4

Reactant 2

HCID 12182Ethyl propiolateHCID 15079741HCID 15079741, compound

Product 1

HCID 15079751HCID 15079751, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner given in Example 1, 2-amino-8-ethylthio-5-(m-fluorophenyl)-3H-1,4-benzodiazepine, ethyl propiolate and ethanol were refluxed. The mixture was chromatographed to give 10-ethylthio-7-(m-fluorophenyl)pyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one.

Workup

  1. temperaturewere refluxed
  2. customThe mixture was chromatographed

Sources & evidence

ORD record
ord-b06afd51ef264c809082628af1522096
Source dataset
uspto-grants-1990_12
Patent number
US04978753

Reaction notes

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