HCID 12569590, compound → HCID 22153729, compound

HRID 1111207Notes

Reaction equation

HRID 1111207 reaction equation
[C:1]([OH:7])(=O)[CH2:2][C:3]#[C:4][CH3:5].C(N1C=CN=C1)(N1C=CN=C1)=O.[NH2:20][C:21]1[CH2:27][N:26]=[C:25]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=2[Cl:34])[C:24]2[CH:35]=[C:36]([Cl:39])[CH:37]=[CH:38][C:23]=2[N:22]=1>O1CCCC1.CN(C)C=O>[Cl:39][C:36]1[CH:37]=[CH:38][C:23]2[N:22]3[C:3]([CH2:4][CH3:5])=[CH:2][C:1](=[O:7])[N:20]=[C:21]3[CH2:27][N:26]=[C:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[Cl:34])[C:24]=2[CH:35]=1

Participants

4

Reactant 2

HCID 12569590HCID 12569590, compoundHCID 131716735HCID 131716735, compound

Product 1

HCID 22153729HCID 22153729, compound

Reagents, catalysts & solvents 1

HCID 21974620tetrahydrofuran N,N-dimethylformamideSolvent

Procedure

In the manner given in Example 16 carbonyldiimidazole β-pentynoic acid and 2-amino-7-chloro-5-(o-chlorophenyl)-3H-1,4-benzodiazepine were stirred in tetrahydrofuran-di-methylformamide to give 9-chloro-1-ethyl-7-(o-chlorophenyl) pyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one.

Sources & evidence

ORD record
ord-94c50f0dd8f54f6d8b87b8f7e61279e5
Source dataset
uspto-grants-1990_12
Patent number
US04978753

Reaction notes

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