Dimethyl acetylenedicarboxylate → HCID 15079782, compound

HRID 1111215Notes

Reaction equation

HRID 1111215 reaction equation
[NH2:1][C:2]1[CH2:8][N:7]=[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[Cl:15])[C:5]2[CH:16]=[C:17]([Cl:20])[CH:18]=[CH:19][C:4]=2[N:3]=1.[C:21]([C:27](OC)=[O:28])#[C:22][C:23]([O:25][CH3:26])=[O:24]>CO>[C:23]([C:22]1[N:3]2[C:4]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:5]=3[C:6]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[Cl:15])=[N:7][CH2:8][C:2]2=[N:1][C:27](=[O:28])[CH:21]=1)([O:25][CH3:26])=[O:24]

Participants

4

Reactant 2

HCID 12980Dimethyl acetylenedicarboxylateHCID 12569590HCID 12569590, compound

Product 1

HCID 15079782HCID 15079782, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In the manner given in Example 21, 2-amino-7-chloro-5-(o-chlorophenyl)-3H-1,4-benzodiazepine was heated in methanol with dimethyl acetylenedicarboxylate to give 1-carbomethoxy-9-chloro-7-(o-chlorophenyl)pyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one.

Sources & evidence

ORD record
ord-34afbb5f22844e179825c9624402bd6c
Source dataset
uspto-grants-1990_12
Patent number
US04978753

Reaction notes

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