Diethyl acetylenedicarboxylate → HCID 15079783, compound

HRID 1111216Notes

Reaction equation

HRID 1111216 reaction equation
[NH2:1][C:2]1[CH2:8][N:7]=[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[Cl:15])[C:5]2[CH:16]=[C:17]([N+:20]([O-:22])=[O:21])[CH:18]=[CH:19][C:4]=2[N:3]=1.[C:23]([C:30](OCC)=[O:31])#[C:24][C:25]([O:27][CH2:28][CH3:29])=[O:26]>C(O)C>[C:25]([C:24]1[N:3]2[C:4]3[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][C:5]=3[C:6]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[Cl:15])=[N:7][CH2:8][C:2]2=[N:1][C:30](=[O:31])[CH:23]=1)([O:27][CH2:28][CH3:29])=[O:26]

Participants

4

Reactant 2

HCID 69803Diethyl acetylenedicarboxylateHCID 15079735HCID 15079735, compound

Product 1

HCID 15079783HCID 15079783, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner given in Example 27, 2-amino-7-nitro-5-(o-chlorophenyl)-3H-1,4-benzodiazepine was heated in ethanol with diethyl acetylenedicarboxylate to give 1-carboethoxy-9-nitro-7-(o-chlorophenyl)pyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one.

Sources & evidence

ORD record
ord-3d0244c9dad64fc884111eafad655805
Source dataset
uspto-grants-1990_12
Patent number
US04978753

Reaction notes

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