HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 1-hydroxymethyl-9-chloro-7-phenylpyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-carbomethoxy-9-chloro-7-phenylpyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one | HCID 15079781 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-hydroxymethyl-9-chloro-7-phenylpyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one | HCID 15079790 | — |
Reaction Steps
A solution of 1 mmole of 1-carbomethoxy-9-chloro-7-phenylpyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one in tetrahydrofuran was reacted at room temperature with the stoichiometric amount of lithium aluminum hydride and stirred for several hours. It was decomposed with water and 15% sodium hydroxide and worked up to give 1-hydroxymethyl-9-chloro-7-phenylpyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04978753 |
| Source dataset | uspto-grants-1990_12 |
| ORD ID | ord-a39f1c1df67646c28f17abe2667c0276 |
| Source note | uspto-grants-1990_12 |