HCID 15079782, compound → HCID 15079791, compound

HRID 1111224Notes

Reaction equation

HRID 1111224 reaction equation
[C:1]([C:5]1[N:10]2[C:11]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:12]=3[C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[Cl:22])=[N:14][CH2:15][C:9]2=[N:8][C:7](=[O:28])[CH:6]=1)(OC)=[O:2].[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[OH:2][CH2:1][C:5]1[N:10]2[C:11]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:12]=3[C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[Cl:22])=[N:14][CH2:15][C:9]2=[N:8][C:7](=[O:28])[CH:6]=1

Participants

3

Reactant 2

HCID 15079782HCID 15079782, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 15079791HCID 15079791, compound

Procedure

In the manner given in Example 37, 1-carbomethoxy-9-chloro-7-(o-chlorophenyl)pyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one was reduced with lithium aluminum hydride to give 1-hydroxymethyl-9-chloro-7-(o-chlorophenyl)pyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one.

Sources & evidence

ORD record
ord-99a0795f6d0a4671903080be3e18650b
Source dataset
uspto-grants-1990_12
Patent number
US04978753

Reaction notes

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