Succinic anhydride → HCID 131716737, compound

HRID 1111228Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[CH:12]=[CH:13][C:14](=[O:16])[N:15]=[C:10]3[CH:9]([OH:17])[N:8]=[C:7]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:24])[C:6]=2[CH:25]=1.[C:26]1(=[O:32])[O:31][C:29](=[O:30])[CH2:28][CH2:27]1>>[C:26]([OH:31])(=[O:32])[CH2:27][CH2:28][C:29]([OH:16])=[O:30].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[CH:12]=[CH:13][C:14](=[O:16])[N:15]=[C:10]3[CH:9]([OH:17])[N:8]=[C:7]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:24])[C:6]=2[CH:25]=1.[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[CH:12]=[CH:13][C:14](=[O:16])[N:15]=[C:10]3[CH:9]([OH:17])[N:8]=[C:7]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:24])[C:6]=2[CH:25]=1

Participants

Reactant 2

HCID 7922Succinic anhydride

HCID 15079826HCID 15079826, compound

Product 1

HCID 131716737HCID 131716737, compound

Procedure

In the manner given in Example 43, 9-chloro-5-hydroxy-7-(o-chlorophenyl)pyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one was treated with succinic anhydride to give 9-chloro-5-hydroxy-7-(o-chlorophenyl)pyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one hemisuccinate.

Sources & evidence

ORD record: ord-e5bd38e995e04d5c9c71913b500a5dfd
Source dataset: uspto-grants-1990_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04978753

Reaction notes

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