Sodium Hydroxide → HCID 14052773, compound

HRID 1111240Notes

Reaction equation

HRID 1111240 reaction equation
[C:1]([CH:3]([O:11][N:12]=[C:13]([C:22]1[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][CH:23]=1)[C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=1)[CH2:4][CH2:5][C:6]([O:8]CC)=[O:7])#[N:2].[OH-].[Na+]>O1CCOCC1>[C:1]([CH:3]([O:11][N:12]=[C:13]([C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=1)[C:22]1[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][CH:23]=1)[CH2:4][CH2:5][C:6]([OH:8])=[O:7])#[N:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 14052772HCID 14052772, compound

Product 1

HCID 14052773HCID 14052773, compoundYield 97.8%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3.96 g of the 4,4'-dimethoxybenzophenone O-(1-cyano-3-ethoxycarbonylpropyl)oxime was dissolved in 20 ml of dioxane and 3 ml of a 5N aqueous solution of caustic soda was added thereto. Then the mixture was allowed to react at 60° C. for five hours. After the completion of the reaction, the reaction mixture was acidified and extracted with ethyl acetate. Thus 3.6 g of the title compound was obtained in the form of a colorless oily product.

Workup

  1. customto react at 60° C. for five hours
  2. customAfter the completion of the reaction
  3. extractionextracted with ethyl acetate

Sources & evidence

ORD record
ord-829aab447731410abfbd5dde367531f7
Source dataset
uspto-grants-1990_12
Patent number
US04978767

Reaction notes

Loading…