HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1111266Generated: November 1, 2026
Methyl iodide → N-[2-(Methylsulfanyl)ethyl]-4-nitroaniline
https://huagongshe.com/reaction/1111266
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Cysteamine Hydrochloride | HCID 9082 | — |
| Reactant | p-Fluoronitrobenzene | HCID 9590 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | N-[2-(Methylsulfanyl)ethyl]-4-nitroaniline | HCID 14646022 | — |
Reaction Steps
A solution of 0.4 mole of sodium hydroxide in 100 ml of water is added dropwise at 30° C. to a solution of 0.4 mole (45.4 g) of 2-aminoethanethiol hydrochloride and 0.4 mole (56.8 g) of methyl iodide in 100 ml of water. After a further hour of stirring at 40° C., 0.15 mole (21.2 g) of 4-fluoronitrobenzene and 42 ml of triethylamine are added.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04979961 |
|---|
| Source dataset | uspto-grants-1990_12 |
|---|
| ORD ID | ord-1544e2f0c9ce450da58d7dc868bc2317 |
|---|
| Source note | uspto-grants-1990_12 |
|---|
