HCID 14836841, compound → HCID 14836843, compound

HRID 1111359Notes

Reaction equation

HRID 1111359 reaction equation
[F:1][C:2]([F:17])([F:16])[O:3][C:4]1[CH:15]=[CH:14][C:7]([NH:8][CH2:9][CH2:10][C:11]([NH2:13])=O)=[CH:6][CH:5]=1>S(=O)(=O)(O)O>[F:1][C:2]([F:16])([F:17])[O:3][C:4]1[CH:15]=[CH:14][C:7]([NH:8][CH2:9][CH2:10][C:11]#[N:13])=[CH:6][CH:5]=1

Participants

3

Reactant 1

HCID 14836841HCID 14836841, compound

Product 1

HCID 14836843HCID 14836843, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

3-(4-Trifluoromethoxyanilino)propionamide may be prepared in the following manner: 3-(4-trifluoromethoxyanilino)propionitrile (5.4 g), obtained in Example 1, and concentrated sulphuric acid (20 cc) are heated to 90° C. for 2 hours. After cooling to a temperature of 20° C., this solution is added to ice (250 g) and the pH is brought to 9-10 with concentrated sodium hydroxide (10N). 3-(4-Trifluoromethoxyanilino)propionamide (4.2 g), m.p. 76° C., is thereby isolated directly.

Sources & evidence

ORD record
ord-fdead7de51e049be847165395d63eb74
Source dataset
uspto-grants-1990_12
Patent number
US04980356

Reaction notes

Loading…