Methanol → Methyl 1H-indole-2-carboxylate

HRID 1111377Notes

Reaction equation

HRID 1111377 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10]([OH:12])=[O:11].[CH3:13]O>>[CH3:13][O:11][C:10]([C:2]1[NH:1][C:9]2[C:4]([CH:3]=1)=[CH:5][CH:6]=[CH:7][CH:8]=2)=[O:12]

Participants

3

Reactant 2

HCID 887MethanolHCID 72899Indole-2-carboxylic acid

Product 1

HCID 70992Methyl 1H-indole-2-carboxylate

Procedure

50 g Indole-2-carboxylic acid were stirred with 400 ml methanol/10% H2SO4 for 48 hours. The resulting crystals were filtered off and washed with methanol giving 51.3 g product.

Workup

  1. filtrationThe resulting crystals were filtered off
  2. washwashed with methanol giving 51.3 g product

Sources & evidence

ORD record
ord-f335bf23ae41436fb327c41f9d1736cd
Source dataset
uspto-grants-1990_12
Patent number
US04980368

Reaction notes

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