HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1111378Generated: October 27, 2026
Dimethylamine → 3-Dimethylaminomethyl-2-methoxycarbonylindole
https://huagongshe.com/reaction/1111378
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Methyl 1H-indole-2-carboxylate | HCID 70992 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 3-Dimethylaminomethyl-2-methoxycarbonylindole | HCID 10911423 | — |
Reaction Steps
To 51 g ester from (a) was added a mixture of 38 ml dimethylamine, 40 ml acetic acid and 23.5 ml formaldehyde (35% in water). After 20 hours stirring at 80° C. the mixture was cooled and the product isolated by acid-base separation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04980368 |
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| Source dataset | uspto-grants-1990_12 |
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| ORD ID | ord-3f07e44787614833959c27307d51fde6 |
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| Source note | uspto-grants-1990_12 |
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