HuagongsheHuagongshe Chemistry Print Report · For research reference only
Citric Acid → 2-Carbomethoxy-3-indolylacetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Citric Acid | HCID 311 | — |
| Reactant | Ethyl Bromide | HCID 6332 | — |
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | 3-Dimethylaminomethyl-2-methoxycarbonylindole | HCID 10911423 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 2-Carbomethoxy-3-indolylacetonitrile | HCID 12644422 | — |
Reaction Steps
40.6 g Product from (b) were dissolved in 300 ml DMSO and 14.5 ml ethylbromide were added. After 10 minutes, 11.4 g KCN were added and the mixture was stirred for 48 hours. The reaction mixture was poured into citric acid and extracted with CH2Cl2. The solvent was evaporated to give 26 g yellow residue.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04980368 |
| Source dataset | uspto-grants-1990_12 |
| ORD ID | ord-9083242bed2143cebeecf2b64877daae |
| Source note | uspto-grants-1990_12 |