HuagongsheHuagongshe Chemistry Print Report · For research reference only
P-Xylene → 5-(Tetradecyloxy)-2-furoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | P-Xylene | HCID 7809 | — |
| Reactant | 1-Tetradecanol | HCID 8209 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 5-Bromo-2-furanecarboxylic acid | HCID 68511 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-(Tetradecyloxy)-2-furoic acid | HCID 115175 | — |
Reaction Steps
A mixture of 57.2 (0.300 mole) of 5-bromo-2-furoic acid, 102.0 g (0.45 mole) of tetradecanol, 18.0 g (0.750 mole) of sodium hydride and 2 liters of p-xylene are heated to reflux for 48 hours. The mixture is allowed to cool, then is acidified with acetic acid and diluted with 2 liters of water. The organic layer is separated, dried, evaporated to dryness, and the residue recrystallized from hexane to give 5-tetradecyloxy-2-furoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04980371 |
| Source dataset | uspto-grants-1990_12 |
| ORD ID | ord-9bc6a38a60a74b16a02c7fb17b8e5683 |
| Source note | uspto-grants-1990_12 |