5-(Tetradecyloxy)-2-furoic acid → Ethyl 5-(9,12,15-octadecatrien-1-yloxy)-2-furyl ketone
Reaction equation
[CH2:1]([O:19][C:20]1[O:24][C:23]([C:25]([OH:27])=O)=[CH:22][CH:21]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH:9]=[CH:10][CH2:11][CH:12]=[CH:13][CH2:14][CH:15]=[CH:16][CH2:17][CH3:18].[CH2:28](OC1OC(C(O)=O)=CC=1)[CH2:29]CCCCCCCCCCCC.C([Mg]Br)C.C[Mg]Br>>[CH2:1]([O:19][C:20]1[O:24][C:23]([C:25]([CH2:28][CH3:29])=[O:27])=[CH:22][CH:21]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH:9]=[CH:10][CH2:11][CH:12]=[CH:13][CH2:14][CH:15]=[CH:16][CH2:17][CH3:18]Participants
5
Procedure
When in the procedure of Example 1 (B) an appropriate amount of 5-(9,12,15-octadecatrien-1-yloxy)-2-furoic acid is substituted for 5-(tetradecyloxy)-2-furoic acid, and an appropriate amount of ethyl magnesium bromide is substituted for methyl magnesium bromide, ethyl 5-(9,12,15-octadecatrien-1-yloxy)-2-furyl ketone is obtained.
Sources & evidence
- ORD record
- ord-2cb62ddf44144feebfa48dc793ac25a9
- Source dataset
- uspto-grants-1990_12
- Patent number
- US04980371
Reaction notes
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