Water → Ethyl 2-[6-{1-[(1,1-dimethylethyl)(dimethyl)silyl]-1H-indol-4-yl}-1-(phenylsulfonyl)-1H-indazol-4-yl]-1,3-oxazole-5-carboxylate

HRID 111143Notes

Reaction equation

HRID 111143 reaction equation
[CH2:49]1[O:50][CH2:51][CH2:52][O:53][CH2:54]1.[CH3:30][C:31]([CH3:32])([CH3:33])[Si:34]([n:35]1[cH:36][cH:37][c:38]2[c:39]([B:44]([OH:45])[OH:46])[cH:40][cH:41][cH:42][c:43]12)([CH3:47])[CH3:48].[Cl:1][c:2]1[cH:3][c:4](-[c:20]2[o:21][c:22]([C:25](=[O:26])[O:27][CH2:28][CH3:29])[cH:23][n:24]2)[c:5]2[cH:6][n:7][n:8]([S:11](=[O:12])(=[O:13])[c:14]3[cH:15][cH:16][cH:17][cH:18][cH:19]3)[c:9]2[cH:10]1.[OH2:55]>>[c:2]1(-[c:39]2[c:38]3[cH:37][cH:36][n:35]([Si:34]([C:31]([CH3:30])([CH3:32])[CH3:33])([CH3:47])[CH3:48])[c:43]3[cH:42][cH:41][cH:40]2)[cH:3][c:4](-[c:20]2[o:21][c:22]([C:25](=[O:26])[O:27][CH2:28][CH3:29])[cH:23][n:24]2)[c:5]2[cH:6][n:7][n:8]([S:11](=[O:12])(=[O:13])[c:14]3[cH:15][cH:16][cH:17][cH:18][cH:19]3)[c:9]2[cH:10]1

Participants

5

Reactant 4

HCID 962WaterHCID 312751,4-DioxaneHCID 223523971-(tert-Butyldimethylsilyl)-1H-indole-4-boronic acidHCID 59564714HCID 59564714, compound

Product 1

HCID 59564707Ethyl 2-[6-{1-[(1,1-dimethylethyl)(dimethyl)silyl]-1H-indol-4-yl}-1-(phenylsulfonyl)-1H-indazol-4-yl]-1,3-oxazole-5-carboxylate

Sources & evidence

ORD record
ord-32da90172b3d47fe81606357671f782d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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