Acetonitrile → (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-(imidazo[1,5-a]pyridin-2-ium-2-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Participants

Reaction Conditions

Reaction Steps

In 1 ml of formamide were dissolved 413 mg of 7β-[2-(2-aminothiazole-4-yl)-2-(Z)-methoxyiminoacetamido]-3-hydroxymethyl-3-cephem-4 -carboxylic acid and 354 mg of imidazo[1.5-a]pyridine. To the solution were added 1 ml of acetonitrile and 0.86 ml of triethyl phosphite, and the mixture was stirred at 20 to 25° C. for 10 hours. The resultant product was treated by the manner of Example 32 to give 7β-[2-(2-aminothiazol-4-yl)-2-(Z)-methoxyiminoacetamido]-3-(imidazo [1,5-a]pyridinium-2-yl)methyl-3-cephem-4-carboxylate.

Provenance & Evidence