反应详情

25.6 g (0.25 mol) of acetic anhydride, followed by 27.8 g (0.25 mol) of pivaloyl cyanide, were introduced, in each case at room temperature, into 49.0 g (0.5 mol) of concentrated sulphuric acid. After a further 4 hours' stirring, 150 g of ice water were added to the reaction mixture and the batch was stirred thoroughly. The reaction product which precipitated was filtered off, washed with 100 ml of water and dried. 37.0 g (86% of theory) of trimethylpyruvic acid N-acetylamide were obtained as colorless glistening flakes of melting point 82° to 84° C.; purity, according to gas-chromatographic determination,>98%.

1. stirringthe batch was stirred thoroughly
2. customThe reaction product which precipitated
3. filtrationwas filtered off
4. washwashed with 100 ml of water
5. customdried