Thionyl Chloride → 2,4,5-Trifluoro-3-methoxybenzoyl chloride

Participants

Reaction Steps

To 3-methoxy-2,4,5-trifluorobenzoic acid (9.4 g) was added thionyl chloride (50 ml), the mixture was refluxed for 3 hours and then concentrated. The residue was purified by distillation under reduced pressure to give 3-methoxy-2,4,5-trifluorobenzoyl chloride (8.86 g) as yellow oil, bp 108°-112° C./20 mmHg.

Provenance & Evidence