Dimethylamine → HCID 11735930, compound

Participants

Reaction Steps

To a solution of 30.5 g (202 mmol) of 3-acetamidophenol in 27.5 g (244 mmol) of 40% dimethylamine and 25 ml of methanol, was added 16.4 g (202 mmol) of 37% formalin. The reaction mixture was placed in an ice bath just after the precipitate formed (ABOUT 15 minutes). The white precipitate was filtered after 15-30 minutes, washed with cold water, and air-dried to give 28.0 g (67% yield) of 5-acetamido-2-[(N,N-dimethylamino)-methyl]phenol.

Provenance & Evidence