HCID 14327180, compound → HCID 14327181, compound

Participants

Reaction Steps

To a solution, stirred at ambient temperature, of 2 g of N-ethyl 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl) hydroxymethyl] phenyl sulfonamide, prepared in Example III, in 100 cm3 of acetone, there is added the Jones reagent prepared in accordance with Example II. The reaction mixture is then treated under the same conditions. The carbonyl derivative is purified by passage through a silica gel chromatography column. It is eluted with a 4/1 hexane/ethyl acetate mixture and recrystallized in a hexane/isopropyl ether mixture. 1.5 g of N-ethyl 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl) carbonyl]phenylsulfonamide are obtained.

Provenance & Evidence