Benzene → HCID 22766275, compound

Participants

Reaction Steps

N-(2,2-Diethoxyethyl)-N-(1,3-dioxolan-2-ylmethyl)amine (4 grams), benzene (100 ml), water (100 ml) and sodium carbonate (2 grams) were charged into a glass reaction vessel equipped with a mechanical stirrer and thermometer. The mixture was cooled to a temperature of 5° to 10° C and chloroacetyl chloride (1.5 ml) was added dropwise with stirring. After the addition was completed stirring was continued until the reaction mixture reached room temperature. After this time the organic phase was separated from the aqueous phase and was washed with water. The washed solution was then dried over anhydrous magnesium sulfate, filtered and stripped of solvent under reduced pressure to yield the desired product N-(2,2-diethoxyethyl)-N-(1,3-dioxolan-2-ylmethyl)-α-chloroacetamide as the residue.

Provenance & Evidence