反应详情

5-Bromothiazol-2-yl isocyanate dimer (17.0 grams), benzene (70 ml) and the dimethyl acetal of 2-β-chloroethylaminoacetaldehyde (13.5 grams) are charged into a glass reaction vessel equipped with a mechanical stirrer and thermometer. The reaction mixture is then stirred at room temperature for a period of about 1 hour. After this time the reaction mixture is filtered, and the filtrate is stripped of solvent under reduced pressure, leaving an oil. This oil is dissolved in an ethanol-water mixture, and the solution is filtered. The filtrate is then stripped of solvents under vacuum to yield the desired product the dimethyl acetal of 2-[1-β-chloroethyl-3-(5-bromothiazol-2-yl)ureido]acetaldehyde.

1. customequipped with a mechanical stirrer
2. filtrationAfter this time the reaction mixture is filtered
3. customleaving an oil
4. filtrationthe solution is filtered