Ethylmorpholine → HCID 53789352, compound

Participants

Reaction Steps

A solution of t-butoxycarbonyl-glycyl-asparaginyl-phenylalanyl-phenylalanine methyl ester (0.525 g, 0.879 mmole, described in Example 4) in trifluoroacetic acid (10 ml) is stirred at 0° C. for 90 minutes and evaporated. The residue is dissolved in methanol (1 ml) and diethyl ether (100 ml) is added. The precipitate is collected and dried. A solution of the precipitate, N-ethylmorpholine (0.11 ml, 0.85 mmole) and 3-tritylthiopropionic acid pentachlorophenyl ester (0.556 g, 0.935 mmole) in dimethylformamide (25 ml) is stirred at 0° C. for 1 hour and at 25° C. for 20 hours and evaporated. The residue is triturated with methanol and the precipitate is dried to give the title compound as a powder, mp 234°-236.5° C.

Provenance & Evidence